Wound Healing Potential of Tagetes erecta (Marigold) Flowers: A Comprehensive Review of Phytochemical, Pharmacological, and Clinical Evidence

• Abhishek Joshi

  Bhupal Nobles' College of pharmacy

  Author

• Sakshi Rajput

  Author

• Ayush Salvi

  Author

• Jenam Gandhi

  Author

• Shreya Sharma

  Author

• Aditya Pant

  Author

Tagetes erecta L., commonly known as African or Aztec marigold, represents one of the most extensively studied ornamental plants with significant therapeutic potential in wound management. This comprehensive review synthesizes current evidence regarding the wound healing activity of hydroalcoholic and solvent extracts of T. erecta flowers, examining their phytochemical composition, mechanisms of action, preclinical efficacy in Wistar rat models, and emerging clinical applications. The flower extracts demonstrate multifaceted therapeutic properties through modulation of inflammatory pathways, enhancement of fibroblast proliferation, promotion of collagen synthesis, and acceleration of epithelialization. Key bioactive constituents including lutein, zeaxanthin, quercetin, patuletin, and essential oil terpenoids contribute to antioxidant, anti-inflammatory, and antimicrobial activities essential for tissue repair. Recent advances in nanotechnology-based delivery systems, including chitosan hydrogels and silver nanoparticle formulations, have enhanced the bioavailability and therapeutic efficacy of these extracts. This review critically evaluates 40+ original research papers and clinical studies to provide a robust evidence base supporting the integration of T. erecta flower extracts into modern wound care protocols, while identifying gaps requiring further investigation for clinical translation.

Copyright (c) 2026 Abhishek Joshi, Sakshi Rajput, Ayush Salvi, Jenam Gandhi, Shreya Sharma, Aditya Pant (Author)

This work is licensed under a Creative Commons Attribution 4.0 International License.