Evaluation of Analgesic Activity of Murraya koenigii Linn. Root Extract: A comprehensive review on its Pharmacological and therapeutic insights

• Shreya Sharma

  Bhupal Nobles' College of pharmacy

  Author

• Jenam Gandhi

  Author

• Abhishek Joshi

  Author

• Sakshi Rajput

  Author

• Ayush Salvi

  Author

• Dr. Jai Singh Vaghela

  Author

Murraya koenigii Linn., commonly known as the curry leaf tree, is a medicinal plant widely used in traditional systems of medicine for its diverse pharmacological properties. While extensive research has focused on the leaves, the root extract has received less attention, particularly regarding its analgesic activity. This review paper evaluates the available literature on the analgesic potential of Murraya koenigii root extract, drawing from phytochemical analyses, in vitro and in vivo studies, and related pharmacological activities such as anti-inflammatory effects, which often overlap with analgesia. The plant's roots are rich in carbazole alkaloids like girinimbine and mahanimbine, which contribute to its bioactivity. Studies indicate that crude root extracts exhibit anti-inflammatory properties in models like carrageenan-induced edema, potentially extending to pain relief through mechanisms involving cytokine modulation and antioxidant effects. However, direct evidence for analgesic activity of the root extract is limited, with most data derived from leaf or whole-plant studies. This review explores multiple angles, including phytochemistry, experimental models, mechanisms, edge cases like toxicity, and implications for therapeutic use. It highlights the need for more targeted research on root extracts to validate traditional claims and develop novel analgesics. Fifteen references are cited to support the discussion, emphasizing real, peer-reviewed sources.

Copyright (c) 2026 Shreya Sharma, Jenam Gandhi, Abhishek Joshi, Sakshi Rajput, Ayush Salvi, Dr. Jai Singh Vaghela (Author)

This work is licensed under a Creative Commons Attribution 4.0 International License.