Research Priorities for a Resilient Healthcare System in India: Integrating Molecular Discoveries, Diagnostic Innovation and Community-Based Interventions

• Parikshit Nagda

  Department of pharmacy practice, Geetanjali Institute of Pharmacy, Udaipur

  Author

• Mahendra Singh Rathore

  Department of pharmacy practice, Geetanjali Institute of Pharmacy, Udaipur

  Author

Healthcare research in India is expanding across molecular biology, clinical medicine, diagnostic technologies and public health. However, the translation of scientific discoveries into accessible healthcare interventions remains a major challenge. Emerging research in biological defence mechanisms, cancer biology, infectious diseases, genetic disorders and clinical therapeutics provides opportunities to strengthen disease prevention and management. At the same time, investigations into healthcare accessibility, community-based screening and primary healthcare delivery highlight the importance of an effective health-system response. This perspective examines selected research developments across these domains and discusses their relevance to strengthening healthcare research and service delivery in India. It also identifies priorities for interdisciplinary collaboration, diagnostic standardisation, regional research infrastructure and evidence-based healthcare implementation.

1. Mahendra Singh Rathore , Department of pharmacy practice, Geetanjali Institute of Pharmacy, Udaipur

   Principle & HOD

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This work is licensed under a Creative Commons Attribution 4.0 International License.

1. References
2. 1. Giri MK, Swain S, Gautam JK, Singh S, Singh N, Bhattacharjee L, et al. The Arabidopsis thaliana At4g13040 gene, a unique member of the AP2/EREBP family, is a positive regulator for salicylic acid accumulation and basal defense against bacterial pathogens. J Plant Physiol. 2014;171(10):860-867. doi:10.1016/j.jplph.2013.12.015.
3. 2. Gautam JK, Giri MK, Singh D, Chattopadhyay S, Nandi AK. MYC2 influences salicylic acid biosynthesis and defense against bacterial pathogens in Arabidopsis thaliana. Physiol Plant. 2021;173(4):2248-2261. doi:10.1111/ppl.13575.
4. 3. Giri MK, Gautam JK, Rajendra Prasad VB, Chattopadhyay S, Nandi AK. Rice MYC2 (OsMYC2) modulates light-dependent seedling phenotype, disease defence but not ABA signalling. J Biosci. 2017;42(3):501-508. doi:10.1007/s12038-017-9703-8.
5. 4. Singh V, Singh D, Gautam JK, Nandi AK. RSI1/FLD is a positive regulator for defense against necrotrophic pathogens. Physiol Mol Plant Pathol. 2019;107:40-45. doi:10.1016/j.pmpp.2019.04.005.
6. 5. Gautam JK, Nandi AK. APD1, the unique member of Arabidopsis AP2 family influences systemic acquired resistance and ethylene-jasmonic acid signaling. Plant Physiol Biochem. 2018;133:92-99. doi:10.1016/j.plaphy.2018.10.026.
7. 6. Mittal D, Gautam JK, Varma M, Laie A, Mishra S, Behera S, et al. External jasmonic acid isoleucine mediates amplification of plant elicitor peptide receptor (PEPR) and jasmonate-based immune signalling. Plant Cell Environ. 2024;47(4):1397-1415. doi:10.1111/pce.14812.
8. 7. Bhattacharjee L, Singh D, Gautam JK, Nandi AK. Arabidopsis thaliana serpins AtSRP4 and AtSRP5 negatively regulate stress-induced cell death and effector-triggered immunity induced by bacterial effector AvrRpt2. Physiol Plant. 2017;159(3):329-339. doi:10.1111/ppl.12516.
9. 8. Singh D, Patil V, Kumar R, Gautam JK, Singh V, Nandi AK. RSI1/FLD and its epigenetic target RRTF1 are essential for the retention of infection memory in Arabidopsis thaliana. Plant J. 2023;115(3):662-677. doi:10.1111/tpj.16252.
10. 9. Gautam JK, Mohanty SS, Babu BV. Prevalence and determinants of oral potentially malignant disorders in western Rajasthan. Sci Rep. 2025;15(1):15611. doi:10.1038/s41598-025-98096-8.
11. 10. Nishad A, Gautam JK, Agarwal I, Nandi AK. Immune priming promotes thermotolerance, whereas thermopriming suppresses systemic acquired resistance in Arabidopsis. Plant Cell Environ. 2025;48(5):3352-3363. doi:10.1111/pce.15364.
12. 11. Gautam JK, Anand PK, Chouhan M, Babu BV. Capacity building of community health officers for optimizing the screening and early diagnosis of oral cancer in Jodhpur, Rajasthan, India. Sci Rep. 2025;15(1):16027. doi:10.1038/s41598-025-00225-w.
13. 12. Anand PK, Patel D, Dewasi G, Gautam JK. Challenges and barriers in implementation of National Tuberculosis Elimination Program guidelines at Nutrition Rehabilitation Centers in India: a systematic review. J Epidemiol Glob Health. 2026;16(1):121. doi:10.1007/s44197-026-00538-7.
14. 13. Thakor M, Gautam JK, Panigrahi A, Garasiya D, Brhamnia SL, Mohanty SS. Operational feasibility of point-of-care testing for sickle cell disease in resource-limited settings of tribal sub-plan region of India. Diagnostics (Basel). 2025;15(3):348. doi:10.3390/diagnostics15030348.
15. 14. Gautam JK, Dewasi G, Khan A, Bhardwaj P. Assessment of Health and Wellness Centres/Ayushman Arogya Mandir in Jodhpur District, Rajasthan, India: a facility-based cross-sectional study [Preprint]. Research Square; 2026 Jun 24. doi:10.21203/rs.3.rs-9933554/v1.
16. 15. Gazta P, Gautam J, Thakor M, Bhardwaj P, Mohanty SS. Role of the primary healthcare providers in sickle cell disease management: a scoping review. J Community Genet. 2026;17(2):35. doi:10.1007/s12687-026-00867-x.
17. 16. Anand PK, Patel D, Lata S, Gautam JK, Chaudhary M, Singh M, et al. Factors associated with pulmonary TB in malnourished children admitted to rehabilitation centres. Int J Tuberc Lung Dis. 2026;30(1):21-26. doi:10.5588/ijtld.25.0338.
18. 17. Gautam JK, Thanvi A, Soni P, Anand PK. Estimation of the proportion and determinants of diabetes mellitus among notified tuberculosis patients in Jaipur, Rajasthan, India. Cureus. 2025;17(3). doi:10.7759/cureus.80319.
19. 18. Anand PK, Kumari R, Gautam JK. Disparities in healthcare seeking and treatment outcomes among tuberculosis-human immunodeficiency virus comorbidity cases: a case series from Jaipur, Rajasthan, India. J Public Health Prim Care. 2026;7(1):77-80. doi:10.4103/jphpc.jphpc_34_25.
20. 19. Choudhary S, Kumar P, Mohanty SS, Anand PK, Gautam JK. Molecular docking of pyocyanin from Pseudomonas aeruginosa with NADPH oxidase and Toll-like receptor 4: exploring the link between oral microbiome and oral cancer pathogenesis [Preprint]. bioRxiv; 2025 Aug 27. doi:10.1101/2025.08.24.671957.
21. 20. Gautam JK, Parashar D, Dewasi G, R T, Gibi J, Anand PK, et al. Community and health system challenges in oral cancer screening in India: a systematic review. BMC Oral Health. 2026. doi:10.1186/s12903-026-10216-6.
22. 21. Anand PK, Raika GR, Gautam J, Bhardwaj P. Mapping the evolution of implementation science: a bibliometric analysis of global and Indian research landscapes. Clin Epidemiol Glob Health. 2026;42:102488. doi:10.1016/j.cegh.2026.102488.
23. 22. Gautam JK, R T, Dewasi G, Parashar D, Bhardwaj P. Barriers and facilitators of oral, breast, and cervical cancer screening in India: a systematic review. BMC Public Health. 2026. doi:10.1186/s12889-026-29309-6.
24. 23. Anand PK, Patel D, Vats K, Gautam JK. Perceptions of healthcare providers in the implementation of National Tuberculosis Elimination Program guidelines at malnutrition treatment centres in Jodhpur, Rajasthan, India: a qualitative study [Preprint]. Research Square; 2026 Aug 31. doi:10.21203/rs.3.rs-10701101/v1.
25. 24. Anand PK, Banerjee P, Dewasi G, Gautam JK. Tuberculosis and associated vulnerabilities among rural residents in Jaipur District, Rajasthan, India: a community-based cross-sectional study [Preprint]. Research Square; 2026 Aug 14. doi:10.21203/rs.3.rs-10364362/v1.
26. 25. Singh J, Gazta P, Gautam JK, Bhardwaj P, Mohanty SS. Exploring barriers to healthcare access among individuals with sickle cell disease and their caregivers in the tribal areas of Rajasthan: application of socio-ecological model. BMC Public Health. 2026. doi:10.1186/s12889-026-28301-4.
27. 26. Jain R, Chouhan D, Gautam JK, Kumawat R. Temporal stability of human serum for the diagnosis of dengue virus by ELISA. Journal on Communications. 2026;21(9):1-7.
28. 27. Kaur M, Gautam JK, Sharma AR, Singh V, Chouhan D, Baghel A, et al. Nanotechnology-based detection of sickle cell disease and thalassemia: a systematic review. Biosensors (Basel). 2026;16(7):373. doi:10.3390/bios16070373.
29. 28. Dewasi G, Nagda P, Bahl G, Jain V, Gupta SK. Myostatin-driven muscle hypertrophy: a double-edged sword in muscle physiology. J Rare Dis. 2025;4:29. doi:10.1007/s44162-025-00086-x.
30. 29. Halder C, Dewasi G, Nagda P. From fibroadenomas to phyllodes: unraveling the spectrum and clinical profile of benign breast diseases. Curr Trends Med Clin Res. 2025;1(1). doi:10.5281/zenodo.16986117.
31. 30. Pareek A, Kanwar P, Bansal R, Maheshwari B, Joshi A, Dewasi G, et al. Surgeon-in-the-loop AI systems in robotic surgery: enhancing precision, efficiency, and personalization: a short narrative review. Curr Trends Med Clin Res. 2025;1(1). doi:10.5281/zenodo.16947522.
32. 31. Dewasi G, Jain S, Saraf M, Vaghela JS. Evaluation of preemptive single dose of pregabalin for postoperative pain control after laparoscopic cholecystectomy: a prospective comparative study from western India. Dolor. 2026;41(2):31-37. doi:10.24875/DOL.M25000032.
33. 32. Tanwar CS, Jain V, Nagda P, Ramani K, Bahl G, Dewasi G, et al. A rare presentation of chronic lower back ache radiating to lower limb in a patient with ankylosing spondylitis with Andersson lesion managed by methotrexate: a case report [Preprint]. Research Square. 2025 May 13. doi:10.21203/rs.3.rs-6459382/v1.
34. 33. Dewasi G. Possible role of thyroid in epilepsy. J Sci Res Technol. 2023;1(6):44-47. doi:10.5281/zenodo.8308519.
35. 34. Nagda P, Rathore UBS, Dewasi G. Systemic light-chain amyloidosis: evolving diagnostic paradigms and emerging therapeutic strategies beyond ANDROMEDA. Curr Trends Med Clin Res. 2026;5(4). doi:10.5281/zenodo.23790867.
36. 35. Nagda P, Dewasi G, Jain S, Godara R. Why Southern Rajasthan needs an ICMR centre: a case for Udaipur, Salumbar and Pratapgarh. Curr Trends Med Clin Res. 2026;5(4). doi:10.5281/zenodo.23791067.
37. 36. Nagda P, Dewasi G, Jain S. The case for an ICMR centre in Southern Rajasthan: a review with focus on Udaipur, Salumbar and Pratapgarh. Curr Trends Med Clin Res. 2026;5(4). doi:10.5281/zenodo.23791206.
38. 37. Dewasi G, Jain S. Ferroptosis in cancer: molecular mechanisms, tumour microenvironment, therapeutic resistance, and clinical translation. J Egypt Natl Canc Inst. 2026;38(1):80. doi:10.1186/s43046-026-00419-x.
39. 38. Dewasi G, Nagda P, Jain S, Soni S. Pre-operative single 150 mg dose of pregabalin for postoperative pain management in laparoscopic cholecystectomy: a systematic review and meta-analysis [Preprint]. medRxiv. 2026 Jul 13. doi:10.64898/2026.07.11.26357848.