From Lipids to Ligaments: The Surprising Link Between Statins and Bone Health

• Rufaida Wasim

  Rufaida@0805

  Author

• Sumaiya Azmi

  Author

• Aamir Anwar

  Author

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Background: The main purposes of statins, commonly referred to as HMG-CoA reductase inhibitors, are to decrease cholesterol and lower the risk of cardiovascular disease (CVD). According to recent studies, statins can additionally enhance bone health by influencing the processes involved in bone remodeling.

Objective: The purpose of the article is to assess the preclinical and clinical data currently available on how statin medication affects bone mineral density (BMD), osteoporosis risk, and fracture reduction.

Methods: To evaluate the impact of statins on bone metabolism, a thorough assessment of preclinical data, observational studies, and randomized controlled trials (RCTs) was carried out. To explain discrepancies in results, variables including patient characteristics, statin class, dosage, and length of therapy were considered.

Result: According to preclinical research, statins promote bone formation by increasing osteoblast development and preventing osteoclast-mediated bone resorption. A number of observational studies and meta-analyses show that statin use is positively correlated with both higher BMD and a lower risk of osteoporotic fractures. Randomized trials, however, provide conflicting results; many do not demonstrate statistically significant advantages, most likely as a result of differences in research design, population size, and treatment settings.

Conclusion: Existing clinical data is unclear, despite preliminary findings suggesting a positive function of statins to safeguard bone health. Large-scale, carefully planned RCTs are necessary to elucidate their safety and effectiveness in conditions pertaining to the bones. Statins may be a promising adjuvant treatment for osteoporosis, particularly for those who already have CVD.

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1. Sumaiya Azmi

   Assistant Professor, Department of Periodontics

2. Aamir Anwar

   Research Scholar, Faculty of Pharmacy

Copyright (c) 2025 Rufaida Wasim, Sumaiya Azmi, Aamir Anwar (Author)

This work is licensed under a Creative Commons Attribution 4.0 International License.