Analysis of Severe Anemia Management in a Tertiary Care Hospital: A Prospective Observational Study

• Pravesh Bhattarai Chettri

  Karnataka College of Pharmacy

  Author

• Balakeshwa Ramaiah

  Karnataka College of Pharmacy

  Author

• B R Prabhudeva

  Karnataka college of Pharmacy

  Author

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ABSTRACT

Background

Severe anemia is a serious health concern, especially in tertiary care hospitals, where patients frequently present with multiple complaints . It is essential to understand the various patterns, causes, and treatment approaches for optimising patient care. This study aims to evaluate the etiology, treatment approaches, and clinical outcomes in the management of severe anemia.

Materials and methods

Study included 85 patients diagnosed with severe anemia (hemoglobin <7.7 g/dl). Patients were followed up daily, and their demographic, laboratory, medication, and blood transfusion details were collected and analysed.

Results

The demographic of 85 patients showed mean age of 56.7 ± 15.2 years. Majority were above 60 years (43.52%), and male (58.8%) patients were more. The average hospital stay duration was 1.8 ± 1.2 weeks, whereas 44.7% discharged within one week.  The NCNC (64.70%) anemia was the most prevalent morphological form, and ACD (60%) was the etiological form. The major comorbidities were hypertension (52.9%) and diabetes mellitus (48.2%). Most prescribed drug combination therapy was MVI plus thiamine (50%). All the treatment regimens, including PRBC transfusion (8.8%) and erythropoietin (21.1%), significantly increased the hemoglobin concentration. from baseline to final value (95%CI, 6.66 ± 0.77 g/dL vs 8.44 ± 1.21 g/dL, P < 0.001). One case of an adverse reaction following PRBC transfusion was reported.

Conclusion: Treating severe anemia with combination therapy, PRBC transfusion, and erythropoietin was effective because it significantly increased the hemoglobin concentration. The LOS of patients also depends on the comorbidities.

The data supporting this study are available from the corresponding author upon reasonable request. Patient-level data cannot be shared  publicly due to confidentiality restrictions.

Copyright (c) 2026 Pravesh Bhattarai Chettri, Balakeshwa Ramaiah, B R Prabhudeva (Author)

This work is licensed under a Creative Commons Attribution 4.0 International License.