Revolutionizing Cystic Fibrosis: Unwinding the Complexities for Innovative Therapeutic Insights

• Aashul Nagora

  Author

• Varsha Soni

  Author

• Ayush Sharma

  Author

• Anukrati Joshi

  Author

• Abhishek pareek

  Author

• PDF

Cystic fibrosis (CF) is a genetic disorder caused by CFTR mutations, disrupting ion transport and causing mucus accumulation. This review highlights groundbreaking advancements in CF management, including CFTR modulator therapies, nanotechnology, and gene-editing techniques like CRISPR-Cas9. Personalized medicine and nanoparticles revolutionize treatment by targeting molecular roots, improving efficacy, and reducing side effects. Epidemiological insights, diagnostic innovations, and multidisciplinary management strategies underscore the importance of addressing global disparities in CF care. Emerging therapies, such as triple-combination drugs and CRISPR-based genome editing, offer hope for a comprehensive cure. These advances highlight the need for ongoing research to improve therapies and patient outcomes.

1. Aashul Nagora

   Junior Scientific Assistant

2. Varsha Soni

   M.Pharm, Pharmacology
   Pharmacology Assistant Professor,
   Rai University, Ahmedabad.

3. Ayush Sharma

   Assistant Professor, RUHS CPS, Jaipur, Rajasthan

4. Anukrati Joshi

   Resident doctor, Department of General Medicine, Ananta institute of medical sciences and research centre.

5. Abhishek pareek

   Resident Doctor, Department of General medicine, AIMS & RC

Copyright (c) 2025 Aashul Nagora, Varsha Soni, Ayush Sharma, Anukrati Joshi, Abhishek pareek (Author)

This work is licensed under a Creative Commons Attribution 4.0 International License.